منابع مشابه
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Cigarette smoking and the use of smokeless chewing tobacco have been closely tied to the development of several human cancers, including lung, oral, esophageal, and bladder. Additionally, individuals exposed to tobacco or tobacco smoke have a substantially increased risk of cardiovascular diseases, destructive periodontitis, and pulmonary, immunological, and gastric dysfunction. Although smokin...
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The paper by Muniz Ortiz et al. (2009) in this issue of Toxicological Sciences extends a long line of research on the role of glutathione (GSH) in the metabolism and toxicity of arsenic (As). These investigators used Drosophila as their model organism and the tools of classical and molecular genetics to investigate the genetic basis of variation in sensitivity to the toxic effects of inorganic ...
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The key unanswered question in the particulate matter (PM)related health concern is the biological plausibility of the association between PM and the observed adverse cardiopulmonary health effects. These adverse health outcomes have been demonstrated by both cross-sectional and time-series epidemiological studies. Key to the validity of the biological plausibility is the need to identify the c...
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Conversion of arsenate to arsenite is a critical event in the pathway that leads from inorganic arsenic to a variety of methylated metabolites. The formation of methylated metabolites influences distribution and retention of arsenic and affects the reactivity and toxicity of these intermediates. Indeed, some of the toxic and carcinogenic effects associated with exposure to arsenate or arsenite ...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2000
ISSN: 1096-0929
DOI: 10.1093/toxsci/56.1.1